Perhexiline interactions
WebAbstract Perhexiline, 2- (2,2-dicyclohexylethyl)piperidine, was originally developed as an anti-anginal drug in the 1970s. Despite its success, its use diminished due to the occurrence of poorly understood side effects including neurotoxicity and hepatotoxicity in a small proportion of patients. WebFeb 15, 2015 · Perhexiline promotes HER3 internalization and degradation. In contrast to the other members of the HER family of receptor kinases, the HER3 receptor is not an active kinase [].As a result, strategies targeting the kinase activity to develop small molecule therapeutics against HER3 similar to those employed to develop small molecules against …
Perhexiline interactions
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WebCases of perhexiline toxicity have been reported with Selective serotonin (5HT) uptake inhibitors such as fluoxetine, paroxetine and citalopram. These drugs have been shown to … Webboth perhexiline and hydroxyperhexiline fluctuate in parallel over the day, which might occur if metabolism of perhexiline to its hydroxy metabolite is rapid and/or occurs presystemically. This assumption may also not be accurate. A few cases of drug interactions with perhexiline have been reported in the literature [21–23] but unfor-
WebAug 5, 2024 · Perhexiline relieves symptoms of angina, improves exercise tolerance, and increases the workload needed to induce ischaemia when used as monotherapy. The … WebSpecific drug interactions and management suggestions may be determined by using the Lexicomp drug interactions program included with UpToDate. Refer to UpToDate topics on specific agents and indications for further details. CYP2D6: cytochrome P450 2D6. * Not available in United States. Data from: Lexicomp Online (Lexi-Interact).
WebAbstract Perhexiline, 2- (2,2-dicyclohexylethyl)piperidine, was originally developed as an anti-anginal drug in the 1970s. Despite its success, its use diminished due to the occurrence … WebDrug Interactions Increased plasma concentration with CYP2D6 inhibitors [e.g. SSRI (e.g. paroxetine, fluoxetine), TCA, neuroleptics, narcotic analgesics]. May increase risk of …
WebWhat might happen: The amount of perhexiline in your blood may increase and cause side effects such as dizziness, nausea, vomiting, headaches, loss of appetite, abdominal pain, weakness, and...
WebJun 1, 2014 · Adverse effects (such as abnormal liver function tests, nausea, ataxia and hypoglycaemia) are seen when serum perhexiline concentrations exceed 0.60 mg/L. [5] … childlike personalityWebbeginning of content Active ingredient: perhexiline. The medicines below all contain the following active ingredient(s): perhexiline. You can select a medicine from this list to find out more - including side effects, age restrictions, food interactions and whether the medicine is subsidised by the government on the pharmaceutical benefits scheme (PBS). childlike preferencesWebPerhexiline was introduced about 30 years ago and rapidly gained a reputation for efficacy in the management of angina pectoris. However, hepatic and neurological adverse effects associated with perhexiline administration led to a marked decline in its use. childlike person crosswordWebSerious Interactions . These medications may interact and cause very harmful effects. Consult your healthcare professional (e.g., doctor or pharmacist) for more in formation. childlike playfulnessWebJun 1, 2014 · Adverse effects (such as abnormal liver function tests, nausea, ataxia and hypoglycaemia) are seen when serum perhexiline concentrations exceed 0.60 mg/L. [5] Perhexiline is cleared primarily via formation of mono-hydroxy metabolites (OH-perhexiline) by cytochrome P450 2D6 (CYP2D6), which displays genetic polymorphism. childlike personality disorderWebstructural considerations, that reminiscent of this maleate interaction, perhexiline’s putative biological targets might also have a group equivalent to two oxygen atoms separated by 4.49 A . However, attempts to predict perhexiline’s function based on structural similarities childlike personality traitsWeb890 rows · Apr 7, 2024 · Perhexiline may increase the arrhythmogenic activities of Bepridil. Beractant: Perhexiline may ... gouache paint is similar to poster paint