Ctbp-interacting protein
WebMay 1, 2024 · Typical for multivalent adaptor proteins, CtIP contains various short linear sequence motifs facilitating interactions between protein-binding partners, some of which are governed by CtIP phosphorylation (Fig. 1) [2, 24].For instance, CDK-mediated phosphorylation of CtIP at S327 is a prerequisite for the binding of BRCA1 BRCT … WebMechanistically, PGAM1 facilitates DSB end resection by regulating the stability of CTBP-interacting protein (CtIP). Knockdown of PGAM1 in cancer cells accelerates CtIP degradation through deprivation of the intracellular deoxyribonucleotide triphosphate pool and associated activation of the p53/p73 pathway.
Ctbp-interacting protein
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WebZEB1 is also having its own protein-interacting domain that shows its affinity toward Smad, CtBP, and p300-p/CAF. In addition, ZEB1 contains E -boxes, which are responsible to bind cofactors. ZEB1 regulates the targeted gene expression both positively and negatively by recruiting its cofactors [47] . WebFeb 11, 2005 · Carboxyl-terminal binding protein (CtBP) is a transcriptional corepressor that interacts with a wide variety of cellular factors and carries out important functions in development, cell-cycle regulation, and transformation ().Microarray assays of mouse embryo fibroblasts (MEFs) derived from animals engineered to contain mutations in the …
WebStructural and Functional Analyses of CtBP. The crystal structures of the N-terminal two-thirds of both human CtBP1/2 (16, 17) and rat CtBP/BARS have been solved, providing … C-terminal-binding protein interacting protein (CtIP) is a binding partner with CtBP, which contribute to transcription repression and cell cycle regulation, and which have a role in the cellular response to DNA damage. Interactions. CTBP1 has been shown to interact with: See more C-terminal-binding protein 1 also known as CtBP1 is a protein that in humans is encoded by the CTBP1 gene. CtBP1 is one of two CtBP proteins, the other protein being CtBP2. See more The CtBP1 protein was originally identified as a human protein that bound a PLDLS motif in the C-terminus of adenovirus E1A proteins. It and the related protein CTBP2 were later shown to … See more • Chinnadurai G (2002). "CtBP, an unconventional transcriptional corepressor in development and oncogenesis". Mol. Cell. 9 (2): 213–24. doi:10.1016/S1097-2765(02)00443-4. PMID 11864595. • Schaeper U, Boyd JM, Verma S, et al. (1995). See more CTBP1 has been shown to interact with: • ACTL6B, • ARF, • EVI1 • FOXP2, • HDAC1, • IKZF1, See more • Human CTBP1 genome location and CTBP1 gene details page in the UCSC Genome Browser. • Overview of all the structural information available in the PDB for See more
WebOct 23, 2024 · Abstract Human C-terminal binding protein (CtBP)-interacting protein (CtIP) is a central regulator to initiate DNA end resection and homologous recombination (HR). Several studies have shown that post-translational modifications control the activity or expression of CtIP. WebJan 30, 2006 · Most of the factors that interact with CtBP are transcriptional regulators and bind to CtBP through a conserved Pro-X-Asp-Leu-Ser (“PXDLS”) CtBP-binding domain that is necessary and probably sufficient for the interaction (11, 12).It has recently been shown that CtBP-containing protein complexes include several factors that coordinate …
WebCtIP is a transcriptional co-regulator that binds a number of proteins involved in cell cycle control and cell development, such as CtBP (Cterminus-binding protein), BRCA1 (breast … small group models for churchesWebJan 24, 2024 · CtIP Antibody (D-4) is an IgG 2b κ mouse monoclonal CtIP antibody (also designated RB Binding Protein 8 antibody, Retinoblastoma-Binding Protein 8 antibody, … small group movie freeWebApr 3, 2024 · MRN复合物识别DSBs，结合到DNA末端，修复第一步就是要将DNA末端进行修剪，MRN复合物和转录因子CtIP（CtBP-interacting protein）促进DNA末端切割过 … song the best day of my lifeWebMar 21, 2024 · CTBP1 (C-Terminal Binding Protein 1) is a Protein Coding gene. Diseases associated with CTBP1 include Hypotonia, Ataxia, Developmental Delay, And Tooth Enamel Defect Syndrome and Chromosome 4P Deletion . small group movieWebJul 28, 2000 · The results indicate that E1a's interaction with CtBP activates at least three epithelial cell adhesion gene promoters. The E-cadherin repressor appeared to be the CtBP-interacting protein δ EF1 ... small group movie reviewWebMay 22, 2024 · C-terminal Binding Proteins (CtBP1/2) are evolutionarily conserved metazoan transcriptional co-regulators, with the founding paralog CtBP1 initially identified as a phospho-protein that interacted with the C-terminus of the adenovirus E1A protein. 1-3 Extensive genetic studies in model organisms demonstrate that CtBP is required for … small group molokini snorkel tourWebOct 17, 2003 · Like other E1A binding proteins, CtBP also interacts with a wide variety of cellular factors, many of which have been characterized as DNA binding transcriptional repressors ( Chinnadurai 2002 ). Thus, CtBP … song the bible and the belt