Cisplatin function

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August undefined, 2024

WebNCI's Dictionary of Cancer Terms provides easy-to-understand definitions for words and phrases related to cancer and medicine. WebAug 6, 2014 · Cisplatin and other platinum derivatives are the most widely used chemotherapeutic agents to treat solid tumors including ovarian, head and neck, and testicular germ cell tumors. A known complication of …

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WebThe repair function of MMR proteins has been reported to be uncoupled from their function in mediating cisplatin-induced cell death [56–58]. Since the primary mechanism of cisplatin involves DNA damage and p53 is also involved in DNA damage signaling, there are many studies that correlate cisplatin and DNA damage and repair with p53 activity ... WebApr 14, 2024 · Among the extracellular vesicles, apoptotic bodies (ABs) are only formed during the apoptosis and perform a relevant role in the pathogenesis of different … sharps sofas

Cisplatin - Wikipedia

WebSep 15, 2024 · Cisplatin forms irreversible covalent links with DNA, causing cross linking of DNA chains as well as breaks in the DNA chain and missense mutations. The DNA injury … WebCisplatin (DDP) is a common therapeutic option for non-small cell lung carcinoma (NSCLC). However, some patients fail to respond to the DDP chemotherapy. Therefore, identifying novel biomarkers to improve the diagnosis and treatment of NSCLC is important. porsche 997 gt3 intake manifold

Nephrotoxicity as a Dose-Limiting Factor in a High-Dose Cisplatin …

(PDF) Cisplatin dose adjustment in patients with renal impairment ...

WebSep 1, 2024 · Cisplatin for injection is indicated for the treatment of advanced testicular cancer. Advanced Ovarian Cancer Cisplatin for injection is indicated for the treatment of … WebCisplatin, a chemotherapy medication used to treat BC, not only rapidly kills proliferating cancer cells but also affects the tumor immune microenvironment. However, the mechanism underlying this phenomenon is largely unknown. porsche 997 front grill meshWebJan 11, 2024 · Cisplatin is a heavy metal compound that is cleared by glomerular filtration and renal tubular secretion. Cisplatin forms DNA crosslinks and adducts through oxidative stress injury. porsche 997 gt2rs for sale

"WebCisplatin has disturbed mitochondrial function and dynamics, dysregulate redox status and induced mitophagy and apoptosis, in the other hand semaglutide treatment has normalized dysregulated mitochondrial function and dynamics, … " - Cisplatin function

Cisplatin function

WebCisplatin is administered to cancer patients intravenously as a sterile saline solution (that is, containing salt—specifically, sodium chloride). Once cisplatin is in the bloodstream, it … WebCisplatin is a chemotherapeutic drug but induces acute tissue injury. Oleuropein (OLE) is a major phenolic compound and used as a possible natural antioxidant, antimicrobial, and anticancer agent. We hypothesized that antioxidant activity of OLE may decrease cisplatin-induced oxidative stress and prevent to the development of chemotherapeutic ...

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WebApr 6, 2024 · Cisplatin is a cytostatic agent and it is used to treat various cancer types, including cancer of ovary, testis, lung, head, neck, bladder, neuroblastoma, and nephroblastoma, and Hodgkin’s disease and non-Hodgkin lymphoma. Uses muscle relaxant (skeletal) Uses Used as an antineoplastic Uses antitumor agent Definition WebApr 14, 2024 · Histone acetylation plays a vital role in organizing chromatin, regulating gene expression and controlling the cell cycle. The first histone acetyltransferase to be identified was histone acetyltransferase 1 (HAT1), but it remains one of the least understood acetyltransferases. HAT1 catalyzes the acetylation of newly synthesized H4 and, to a …

WebCisplatin has been a mainstay of cancer chemotherapy since the 1970s. Despite its broad anticancer potential, its clinical use has regularly been constrained by kidney toxicities. … WebNov 10, 2024 · Many widely-used chemotherapies, like cisplatin, kill tumors by damaging their DNA and inducing programmed cell death. But cells are resilient, and many can continue to function with the help of repair enzymes that simply bypass the damage and continue to replicate the DNA.

WebThe cisplatin molecule binds with a protein on one side and the DNA molecule on the other. The protein is critical; it protects the cisplatin molecule from being removed by DNA repair mechanisms in the cell. New combination regimens are often tried in clinical trials, and it is common for newly … WebJan 3, 2024 · Assessment of kidney function; Bleomycin-induced lung injury; Chemotherapy and radiation-related hemorrhagic cystitis in cancer patients; …

WebJan 17, 2014 · Cisplatin is a widely used and highly effective cytotoxic agent, including for nasopharyngeal carcinoma (NPC). One of the side effects of cisplatin is nephrotoxicity, especially in tubulus....

WebCisplatin stimulates production of reactive oxygen species and oxidative stress by depleting and inactivating glutathione and other related antioxidants. • Cisplatin induces both … porsche 997 radiator grillsWebFeb 16, 2024 · Aluminum reacts with this drug, causing precipitate formation and a loss of potency. Monitoring: Peripheral blood counts should be monitored weekly. Liver function should be monitored periodically. Neurologic examination should be performed regularly. More about cisplatin Further information sharps suppliesWebFeb 16, 2016 · Cisplatin is standardly dosed in a three-weekly schedule of 100 mg/m 2 (total dose 300 mg/m 2) combined with standard RT [ 3, 6, 7, 9, 10 ]. However, a high-dose cisplatin regimen is associated with major toxic side effects (myelosuppression, neurotoxicity, ototoxicity, and nephrotoxicity). sharps sporting rifleWebAcute kidney injury is a known side effect of cisplatin treatment, and kidney dysfunction results in the accumulation of uremic toxins in the serum. The present study aimed to investigate whether indoxyl sulfate (IS), a representative uremic toxin, affects the pathophysiology of EOC. ... These findings demonstrate that IS promotes malignancy in ... porsche 997 ignition coilsWebTMEPAI was known to be induced by TGF-β/Smad signaling and have tumorigenic functions that converting TGF-β from tumor suppressor to tumor promoter and inducing epithelial–mesenchymal transition (EMT). ... (IC50) of several anti-cancers: doxorubicin, cisplatin, paclitaxel, and bicalutamide in the presence of TGF-β treatment.Results: KO ... sharps signageWebJul 22, 2024 · Cisplatin is a potent and valuable chemotherapy agent used to treat a broad spectrum of malignancies. Renal tubular dysfunction and a cumulative impairment in … porsche 997 headlight washer nozzle removalWebWhat is cisplatin? Cisplatin is a chemotherapy drug used to treat testicular, ovarian, bladder, head and neck, lung and cervical cancer. It may also be used to treat other … porsche 997 headlight upgrade