Chromopyrrolic
Chromopyrrolic acid is a pyrroledicarboxylic acid that is pyrrole-2,5-dicarboxylic acid in which the hydrogens at positions 3 and 4 have been replaced by indol-3-yl groups. It has a role as a bacterial metabolite. It is a member of indoles and a pyrroledicarboxylic acid. Web开馆时间:周一至周日7:00-22:30 周五 7:00-12:00; 我的图书馆
Chromopyrrolic
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WebApr 5, 2012 · Chromopyrrolic acid-soaked RebC-10x with bound 7-carboxy-K252c. PDB DOI: 10.2210/pdb4EIQ/pdb; Classification: Oxidoreductase/Oxidoreductase inhibitor; …
Webring rearrangement from indole-3-pyruvic acid and NH4+ by the action of chromopyrrolic acid synthase (VioB or StaD) (Asamizu et al. 2007; Hirano et al. 2008). C. violaceum genome analysis showed that the genes trpA–F and pabA–B encode the anthranilate synthase in the tryptophan pathway in the conversion of chorismate to anthranilate (see ... WebJun 29, 2024 · 细胞色素P450结构与催化机理_王斌.pdf,闷 讹 缄 纸 酿 养 秩 疆 悸 赊 邯 碧 匆 倍 七 软 桶 靠 赌 银 钦 踌 肢 箭 甲 楔 逗 聊 俱 挽 顽 婉 梗 冯 薄 佐 娩 充 钡 摸 乏 渣 乙 侍 獭 炙 失 奉 械 迄 砸 志 球 巧 峰 井 告 青 殃 颁 惧 长 币 蝗 鸥 造 试 尺 簇 君 斩 糊 伸 棍 滦 祝 格 撇 瞒 骇 前 赠 言 眠 束 乒 愧 ...
WebJul 3, 2014 · An effective and concise approach to synthesis of tetrasubstituted pyrroles from readily available amino acid esters by the promotion of Cu (OAc)2 in conjunction with Mn (OAc)3 has been developed. This reaction proceeds through multiple dehydrogenations, deamination, and oxidative cyclization. WebJun 6, 2007 · Crystal structures and catalytic mechanism of cytochrome P450 StaP that produces the indolocarbazole skeleton. Staurosporine isolated from Streptomyces sp. …
WebMay 1, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; Furumai, T. Biosci. Biotechnol. Biochem. 2003, 67, 127-138), which proceeds by an unusual C-C bond coupling. Additionally, because CPA is immobilized by a hydrogen-bonding …
WebApr 29, 2024 · What is claimed is: 1. A method of inhibiting or partially inhibiting activity of one or more PIM (proviral integration site for Moloney murine leukemia virus) kinase(s) comprising contacting a PIM kinase with a compound of Formula (I) or Formula (II) or a pharmaceutically acceptable salt, solvate, hydrate, or N-oxide, prodrug, or isotopic … north bethesda maryland zip codeWebMay 1, 2015 · A similar path occurs in the biosynthesis of staurosporine. RebO and RebD can be interchanged with the equivalent StaD and StaP enzymes because chromopyrrolic acid (CPA), 3 or its chlorinated derivative, is common to both paths. Download : Download high-res image (67KB) Download : Download full-size image; Scheme 1. north bethesda gaming chairWebDichlorochromopyrrolate synthase ( EC 1.21.3.9, RebD, dichlorochromopyrrolic acid synthase) is an enzyme with systematic name 2-imino-3- (7-chloroindol-3-yl)propanoate … how to replace vape penWebHoward-Jones, Annaleise R., Walsh, Christopher T. (2006) Staurosporine and Rebeccamycin Aglycones Are Assembled by the Oxidative Action of StaP, StaC, and … north bethesda md csx youtubeWebJan 23, 2006 · Chromopyrrolic acid is indicated by filled arrow head, and indole-3-pyruvic acid is indicated by blank arrow heads. Presumably, because of the coexistence of keto … how to replace valve in showerWebMay 20, 2009 · Chromopyrrolic acid (CPA) oxidation by cytochrome P450 StaP is a key process in the biosynthesis of antitumor drugs (Onaka, H.; Taniguchi, S.; Igarashi, Y.; … north bethesda goddard schoolWebJun 6, 2007 · A key step in staurosporine biosynthesis is the formation of the indolocarbazole core by intramolecular C-C bond formation and oxidative decarboxylation of chromopyrrolic acid (CPA) catalyzed by cytochrome P450 StaP (StaP, CYP245A1). In this study, we report x-ray crystal structures of CPA-bound and -free forms of StaP. north bethesda md city data